RAF Typhoon jets have joined forces with France's air force in a combined operation on an hidden munitions depot in Syria operated by the IS group, according to the UK's MoD.
The facility, located using reconnaissance, was assessed as housing weapons and explosive materials, the release indicated, and was positioned in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes employed precision-guided Paveway IV munitions to target a several access tunnels down to the site... early reports indicate the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the strike late on Saturday and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - imposed militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action shows the UK's leading role, and determination to stand shoulder to shoulder with our partners, to stamp out any revival of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have conducted surveillance missions over Syria to "prevent any attempted comeback" of the group following its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I extend gratitude to every member of British forces participating in this strike for their expertise and their valour," the Defence Secretary said. "Including them were a great many British personnel stationed over the festive period. This mission, to eliminate terrorist threats who endanger our safety, highlights how British military are prepared to act, continuously, ensuring Britain's security within its borders and powerful internationally."
In December, the United States armed forces conducted what it termed a "major assault" on IS targets in the country, after an attack resulted in the deaths of two US troops and a local interpreter in Palmyra.
The UN says Daesh still has roughly 5-7 thousand fighters in both countries.